Fluconazole General Information
Fluconazole is used to prevent and treat a variety of fungal and yeast infections. It belongs to a class of drugs called azole antifungals. It works by stopping the growth of certain types of fungus.
How to Use Fluconazole
Read the Patient Information Leaflet if available from your pharmacist before you start taking Fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take Fluconazole by mouth with or without food as directed by your doctor, usually once daily.
If you are taking the liquid suspension form of Fluconazole, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.
Dosage is based on your medical condition and response to treatment. For children, dosage is also based on weight. Generally in children, the dose should not exceed 600 milligrams daily unless directed by the doctor.
Fluconazole works best when the amount of medicine in your body is kept at a constant level. Therefore, take it at the same time each day as directed.
Continue to take Fluconazole until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow the fungus to continue to grow, which may result in a return of the infection.
Tell your doctor if your condition persists or if it worsens.
Fluconazole Possible Side Effects
Nausea, vomiting, diarrhea, stomach upset/pain, headache, dizziness, or hair loss may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Remember that your doctor has prescribed Fluconazole because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Fluconazole do not have serious side effects.
Get medical help right away if any of these rare but serious side effects occur: fast/irregular heartbeat, severe dizziness, fainting.
Fluconazole may rarely cause serious liver disease. Get medical help right away if you develop any signs of liver disease, including: severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine, unusual tiredness.
A very serious allergic reaction to Fluconazole is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
Before taking Fluconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungal drugs (such as ketoconazole, itraconazole); or if you have any other allergies. Fluconazole may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using Fluconazole, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease.
Fluconazole may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.
The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using Fluconazole, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).
Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using Fluconazole safely.
Although uncommon, Fluconazole may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Older adults may be more sensitive to the side effects of Fluconazole, especially rash, vomiting, diarrhea, and QT prolongation (see above).
During pregnancy, Fluconazole should be used only when clearly needed. It may harm an unborn baby if taken in high doses daily during the first 3 months of pregnancy. Discuss the risks and benefits with your doctor.
Fluconazole passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Fluconazole Possible Intercations
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
Products that may interact with Fluconazole include: clopidogrel.
Many drugs besides Fluconazole may affect the heart rhythm (QT prolongation), including pimozide, quinidine, macrolide antibiotics (such as erythromycin), among others.
Fluconazole can slow down the removal of other medications from your body, which can affect how they work. An example of the affected drugs is cisapride, among others.
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